Direct Immmuno Flourescence Study in Auto Immune Bullous Disorders

Autoimmune vesicobullous disorders in dermatology are numerous ,the diagnosis can be helped by determining morphology of lesion, age group affected , histopathology and immunoflourescence(IF ) . Aim: The aim is to study histopathology of various Autoimmune vesicobullous disorders and its correlation with IF studies in patients attending DVL department, Guntur medical college. Material & Methods : A total of 46 patients of various bullous disorders attending to department of DVL in one & half year period from January 2013 to july 2014 were analysed. of these females (29), males (17), and (3) were children .The clinical features and histopathology were correlated with direct immunofluorescence (DIF) findings. Results: out of 46 patients we studied, females were 29( 6.04 %), males 17(36.95%), children 3 (6.5%). 40 to 60 yrs age group were more commonly affected .we studied & correlated histopathology with IF , of these 24 patients (52.17%) were pemphigus vulgaris. 13 (28.26 %) were bullous pemphigoid. 2 were (4.34%) Dermatitis herpetifiormis, 2 (4.34 %) were pemphigus vegetans, 2 were pemphigus foliaceous(4.34%) , 3 were CBDC ( 6.52%) . Discussion & Conclusion : Histopathology & immunofluorescence findings were correlated in majority (95.5%) of autoimmune bullous disorders except few cases (4.5%) where clinically diagnosed conditions differed from immunoflourescence findings. To conclude, the correlation between clinical findings, Histopathology and Immunofluroscence plays a predominant role to confirm the atypical appearance of autoimmune blistering diseases.